The cees dekker Diaries
The cees dekker Diaries
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‘Yes, which is about suitable. I try to find a Bodily knowledge of Organic devices in a bottom-up way. I believe you could possibly distinguish a few lines of study in my group at the moment. The primary fears chromosome framework: How would you get a metre-long DNA polymer folded and organised in such a microscopic cell? Now we have designed visualisation strategies that enable us to study how, for instance, SMC proteins loop DNA (online video on Youtube) in an effort to build up chromosomes.
You frequently get entangled in discussions about science and religion. You have also prepared quite a few publications on the topic. Don’t you feel that at some point We'll know every thing and that God’s role is going to be above?
[Laughs] ‘It had been undoubtedly an incredible threat! At some time, I had been nicely aware that it could go Incorrect Which I could become a lot less profitable, but I just dismissed that. Curiosity has often been my strongest driving pressure. And fortuitously it all worked out.’
Due to the fact 2000, Dekker has shifted the main emphasis of his do the job in the direction of biophysics wherever he scientific studies the Houses of one biomolecules and cells utilizing the instruments of nanotechnology. This change of discipline was pushed by his fascination for that remarkable functioning of biological molecular buildings, in addition to with the very long-time period standpoint that many intriguing discoveries might be envisioned Within this area.[5] Recent traces of exploration in his biophysics team are during the parts of:[six]
This yielded a breakthrough. Within just only a few months, we were being capable of evaluate transportation by way of a person solitary-walled carbon nanotube. Based on very low-temperature experiments by a brilliant PhD student in my group, Sander Tans (now a valued colleague and professor at Delft University of Know-how with the Energetic research lab at AMOLF in Amsterdam), we showed that carbon nanotubes were being real quantum wires with pretty lengthy (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.
SMC complexes can go physical roadblocks bigger than their ring dimensions, indicating a nontopological system for DNA loop extrusion
We shape bacteria into sorts that deviate from their purely natural phenotype. Precisely, I'll demonstrate our capability to shape Are living E. coli micro organism into novel designs including rectangles, squares, triangles and circles.
Move-pushed rotary motors like windmills and water wheels generate useful procedures in human Modern society. Whilst examples of this kind of rotary motors also characteristic prominently in cell biology, their synthetic building with the nanoscale has remained hard. In this article we show movement-driven rotary motion of a self-arranged ceesdekker DNA nanostructure that is definitely docked on to a nanopore in a skinny stable-point out membrane. An elastic DNA bundle self-assembles right into a chiral conformation on phoretic docking onto the reliable-condition nanopore, and subsequently displays a sustained unidirectional rotary motion of up to 20 rev s−1.
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There was one particular challenge nevertheless — we didn't notice any measurable electrical conduction from the single polymer molecules. We concluded that at The only-molecule degree, conducting polymers had been truly not these kinds of good conductors, which was rather disappointing. We thus broadened our see to try to locate much more promising molecules.
‘The concept that There may be this kind of thing as being a starting, a giant bang, is now an interesting signpost to contemplate that there was a creator. But far more commonly, and on The premise of pure rationality, I also get there in a Christian interpretation of reality. An atheistic worldview is really a naturalistic worldview: fundamentally, you'll find only atoms and normal forces that we can easily evaluate.
Afterwards we spoke yet again briefly for the reason that Dekker felt that our discussion of his faith swiftly grew to become purely philosophical, Whilst Additionally, it concretely aids him in his operate.
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij met enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart style in 2005. (nl)